The group revealed that AIM accumulates on the surface of mice HCC cells, but not on normal cells and showed that AIM interferes with proteins that normally suppress the complement cascade, triggering a process that leads to necrosis and elimination of the cancerous cells. (sciencedaily.com)
Professor Toru Miyazaki's group at the Laboratory of Molecular Biomedicine from Pathogenesis, in the Faculty of Medicine has shown that AIM (also known as CD5L) accumulates on the cell membrane of HCC cells, where it triggers the complement cascade, a highly efficient process of eliminating cancerized cells. (sciencedaily.com)
(Right) In a liver with HCC, AIM accumulates on the cell surface, resulting in the activation of the complement cascade and inducing necrotic cell death. (sciencedaily.com)