Large dogs with this problem tend to suffer from a number of concurrent problems - all related to poor skeletal alignment. (2ndchance.info)
So, what happens in that situation, the body's pancreas which produces insulin, doesn't produce enough insulin where there may be other concurrent problems that the body doesn't react to the insulin appropriately resulting in a very high blood sugar. (whydoesmydog.com)
Subtle weight loss can indicate continuing deterioration of renal function or the presence of a new concurrent problem in older cats, such as hyperthyroidism or IBD. (pettao.com)