The phrase "considerable caution" means that a lot of careful thought and care should be taken before making a decision or taking action. Full definition
There is almost no experimental verification, so considerable caution is needed. (newscientist.com)
Until their adjustment approach is substantially improved, their global temperature estimates should be treated with considerable caution. (oprj.net)
Applying this approach to live, attenuated vaccines would therefore demand considerable caution because blocking responses induced by IL28B might increase the likelihood of side effects. (sciencemediacentre.org)