Highly selected breeds of any plant or animal have considerable drawbacks from an evolutionary standpoint. (religion.blogs.cnn.com)
The only considerable drawback is that all data on the Wii will be erased once the transfer is being made, so there will be no going back from this point onward. (miketendo64.com)
I suspect there may be considerable drawback in the environmental movement as more of the «activists» start coming to the realization that the problem of environmental degradation and extractive processes (of all sorts, not just fossil fuels) is simply not resolvable; that the most unsustainable thing on earth is industrial civilization; that industrial civilization IS itself inherently an extractive process, and that no extractive process is ecologically benign. (earthisland.org)