There is an interesting history behind the use of cox inhibitors for the treatment of TCC in dogs. (vet.purdue.edu)
Aspirin, ibuprofen and the rest of the nonsteroidal anti-inflammatory drugs (NSAIDs) target COX enzymes to muffle prostaglandin production. (sciencedaily.com)
If inflammation stimulated bone growth, he wondered, might normal healing be deterred by anti-inflammatory painkillers, such as Vioxx and Celebrex, that work by inhibiting COX - 2 enzymes? (discovermagazine.com)