The barrier prevents retention of damaged proteins in the stem cell daughter cell keeping the stem cells relatively clean. (sciencedaily.com)
These drugs are known to work by disabling the cell's ability to repair damaged proteins. (newsroom.melbourne.edu)
This could be one of the mechanisms responsible for the reduced regeneration capacity in the aged brain as stem cells that retain larger amounts of damaged proteins require longer for the next cell division. (sciencedaily.com)