They then identified damaging mutations in the children that would disable the protein produced by a particular gene or alter the protein's function. (hhmi.org)
This unique signature could serve as an ideal model to study the effect of demographic processes on human genetic diversity, including the identification of possibly damaging mutations associated with population - specific diseases. (sciencedaily.com)
Such regions are often under negative selection for damaging mutations, meaning that variants should be exceedingly rare. (massgenomics.org)