When the researchers administered drugs called histone deacetylase inhibitors (HDACs)-- which promote acetylation — to mice, they had the same effect as environmental stimulation. (scientificamerican.com)
NAM has been demonstrated to inhibit sirtuin deacetylase activity by a negative feedback. (cellr4.org)
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase Science. (cellr4.org)