Then promise becomes desperation, and once desperation sets in, all bets are off. (sbnation.com)
When a possible medical alternative is refused to your loved one because of bureaucracy, desperation sets in. (screenanarchy.com)
As desperation sets in with the Donald Trump campaign, the Republican National Committee is considering cutting its losses and re-directing funds to save the Republican majorities in the House and Senate. (newrepublic.com)