Functional assessments in BAP1 inactivated, BAP1 wild - type and BAP1 catalytically dead - expressing NCI - H226 and QR mesothelioma cell lines confirmed alteration of these pathways and demonstrated that BAP1 deubiquitinase activity was mandatory to maintain these phenotypes. (science.institut-curie.org)
It was hypothesized that BAP1 tumor suppressor activity could reside, at least in part, in stabilizing proteins through its poly - deubiquitinase activity. (science.institut-curie.org)