The team then blocked the expression of this gene in developing mouse embryos and noticed defects in the formation of the cerebral cortex, a brain region that plays an important role in consciousness. (sciencedaily.com)
The first stretch of DNA showed up in the penile spines of developing mouse embryos, as well as in spots on the face where sensory whiskers would develop, indicating that it caused these structures to develop in response to male hormones. (sciencemag.org)
To do so, the engineered ESCs would be injected into developing mouse embryos, the embryos allowed to develop into chimeric mice (with a fraction of the cells in the adult mice derived from the engineered ESCs), and chimeric adults mated to produce completely transgenic offspring. (blog.addgene.org)