Stanger and Maddipati tested the hunch that clusters of cells of different genetic makeup were better at establishing secondary tumors and found that a significant fraction of metastases involve seeding by more than one type of tumor cell during the natural course of pancreatic tumor progression. (sciencedaily.com)
«The discrepancies we found when comparing cfDNA results to primary tumor results suggested that other sites in the body possibly harbored different genetic makeup than the primary tumor, with potential clinically relevant implications on therapeutic decisions,» Bass said. (sciencedaily.com)
Genotype - environment interaction is a term used by many researchers in relation to twin studies, referring to the potential for people with different genetic makeup to respond differently toward the same external situation (Bergeman et al., 1988). (personalityresearch.org)