This problem led the researchers from the laboratory of Linzhao Cheng (Johns Hopkins) to propose a different strategy to provide SCD patients with the matched red blood cells they require - the generation of induced pluripotent stem cells from SCD patients, the in vitro correction of the mutated hemoglobin gene using CRISPR / Cas9 technology, and the subsequent differentiation of cells into the red blood cells required [2]. (stemcellsportal.com)
The new cellular and molecular data uncovered in the current study will be «exploited in the future to further improve liver bud organoids» and «precisely recapitulate differentiation of all cell types» in fetal human development, the authors write. (sciencedaily.com)
At some subsequent stage differentiation of these cells proceed as they multiply further. (religion-online.org)