The finding adds further credence to a current pharmaceutical effort to create new treatments for diabetic nephropathy, liver fibrosis and other progressive fibrotic and inflammatory diseases, based on blocking these two molecules, both members of the NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (NOX) family of proteins. (sciencedaily.com)
Both are precursors of nicotinamide adenosine dinucleotide (NAD), a critical enzyme involved in more than 300 known redox reactions in the body. (mossnutrition.com)
«Our laboratory investigates the metabolic effects of nicotinamide adenine dinucleotide [NAD +], a metabolite derived from a form of vitamin B3 called nicotinamide,» explained senior author Pavlos Pissios, PhD, an investigator in the Division of Endocrinology, Diabetes and Metabolism at BIDMC and Assistant Professor of Medicine at Harvard Medical School. (sciencedaily.com)