Sinclair and colleagues speculate that these benefits may derive from direct activation of Sir - like genes. (sciencemag.org)
The anti-senescence function of p53 involves direct activation of sestrin genes, which encode proteins that regulate ROS levels and the AMPK / mTOR pathway. (ellisonfoundation.org)
Our studies suggest that direct activation of membrane chloride conductances is a general mechanism of action for biogenic amines in the modulation of C. elegans behavior. (science.sciencemag.org)