The researchers concluded that there are at least two mechanisms at work: direct inhibition of viral replication and a selection for mutations of the virus that limit its strength. (discovermagazine.com)
VPA suppresses Th1 and Th17 cell differentiation and immune function in vitro and in vivo through direct inhibition of Akt. (jimmunol.org)
Since direct inhibition of secretase could induce undesirable side - effects due to inadvertent inhibition of unrelated secretase substrates, it is important to establish methods for inhibiting Aβ production that do not affect secretase activity. (content.iospress.com)