To create cell models for the discovery of disease etiology, progression, and treatment, isogenic cell lines can be created from healthy or sick individuals, then compared (Figure 1). (takarabio.com)
Our findings demonstrate how combining results from diverse experimental approaches with genomewide functional annotations can detect potentially causative variants and give insight into disease etiology, even when genomic data is limited. (hjnoh.com)
«Intuitively, one might expect disease - causing variants to cluster into key pathways that drive disease etiology [the causes of disease],» they write. (gizmodo.com)