The word "downstream" refers to the direction in which a river, stream, or flow of a liquid is flowing. It means to go or move in the opposite direction of where the water or liquid is flowing, from the source to the destination. Full definition
In extreme cases, we may even see total separations or spin - offs as the best way to manage the complexity — much as we have seen the long - term separation of downstream from upstream. (mckinsey.com)
But rather than changes in doublesex itself, these studies revealed changes in downstream targets of dsx, via changes to specific DNA sequences to which DSX protein binds in the cis - regulatory regions of the bric - a-brac and desatF genes and affecting sex differences in abdominal pigmentation and pheromone production. (journals.plos.org)
Under system normal conditions, fluctuations for regulation are typically short lived and generally balance out over the hour with minimal or no noticeable impacts on downstream river flow conditions. (usbr.gov)