The phrase "drug substance" refers to the main ingredient or chemical compound that is present in a medication or drug. It is the active component that gives the drug its intended therapeutic effect on the body. Full definition
Some develop a resistance to certain drug substances, which renders the medication effect less. (sciencedaily.com)
By adding Pink to the state list of controlled substances, it would criminalize possession and sale of the drug (www2.erie.gov)
If you have been convicted of an alcohol or drug - related traffic violation, you may be required to complete an Alcohol and Drug Substance Abuse Course (ADSAC). (dmv.com)