The bacterium that causes whooping cough, Bordetella pertussis, has changed in Australia — most likely in response to the vaccine used to prevent the disease — with a possible reduced effectiveness of the vaccine as a result, a new study shows. (sciencedaily.com)
Conduct large - scale clinical trials involving high - risk populations to determine the full effectiveness of the vaccine. (idri.org)
But this proved disadvantageous because the structure of the mimotope can change retrospectively, leading to reduced effectiveness of the vaccine. (sciencedaily.com)