Furthermore a majority of all inflammation can be traced back to the muscles as they are technically the largest endocrine tissue of the body. (advancedhumanperformance.com)
If the muscles are not functioning properly or are hypertonic / spastic they are actually producing a host of negative byproducts directly from the muscles themselves as well as through crosstalk to other endocrine tissues via mechanisms related to cytokine / myokine function. (advancedhumanperformance.com)
Catechol estrogens have been identified and measured in rat brain and various endocrine tissues with the use of a sensitive radioenzymatic assay. (science.sciencemag.org)