There are pieces still missing, admits Oxford enzymologist Christopher Schofield, one of the research leaders: the gene or genes that the FTO enzyme demethylates, and how that might affect obesity. (sciencemag.org)
Computational simulation of the structure provided clues to the exquisite specificity with which the enzyme recognizes its substrates, solving a mystery that had perplexed enzymologists. (vilcek.org)
Rothman was drawn to his first professorial appointments at Stanford University's Department of Biochemistry by the great enzymologist Arthur Kornberg, who taught him that biochemistry could provide a route to dissecting complex biological systems. (kavlifoundation.org)