We have identified several transcription factors and components of key signaling pathways that are highly expressed in pluripotent epiblast cells of the developing human embryo. (thenode.biologists.com)
Writing in the journal Cell Stem Cell, the team reports that more than half of mouse epiblast stem cells treated with the drug reversed course within three days, and regained an embryonic «be anything» state, also called pluripotency. (uofmhealth.org)
Now, they're working to see if the MM - 401 eraser technique works with human stem cells that bear some resemblance to mouse epiblast stem cells. (uofmhealth.org)