The advantage of the method, compared to targeted mutation experiments in the mouse model system, is cost - efficient gene knock - out in large scale. (scilifelab.se)
For the second paper, the team carried out similar experiments in mice with different doses of nicotine instead of cocaine, showing that the same effects are also true for this drug. (sciencedaily.com)
The researchers performed further experiments in the mice to look for differences in the affected brain cells and the circuits in which they were connected. (sciencedaily.com)