Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes. (abcam.com)
Amino acid deficiency in Slc6a14 − / − tumours was evident from the increased expression of ASNS and CHOP (Figure 3B) and the deficiency of HIF1α was evident from the decreased expression of its target genes coding for the glucose transporter [GLUT1 (Slc2a1)-RSB-, lactate transporter MCT4 (monocarboxylate transpoter 4)(Slc16a3) and VEGF (Figures 3C and 3D). (biochemj.org)
Both studies were published in the New England Journal of Medicine and are the result of a broad collaboration between researchers at the ECOGENE - 21 Clinical and Translational Research Center - linked to the Centre de médecine génique communautaire and the University of Montreal's Department of Medecine in Saguenay, Que. - and ISIS Pharmaceuticals, a Carlsbad, Calif., based company specialised in the development of medications that interfere specifically with the expression of targeted genes. (sciencedaily.com)