In this sense, North Korea would be in extreme disadvantage in a nuclear conflict against the US. (blog.politics.ox.ac.uk)
Ordinarily, when the number of disadvantaged students taking the SAT increases, average scores decline, as those with more extreme disadvantages are drawn into the test - taking pool. (educationnext.org)
They're going to be at an extreme disadvantage in the work force. (sbnation.com)