After a planarian is wounded, the type of injury determines the level fst expression ---- the more extreme the loss of tissue, the higher the level of fst expressed. (sciencedaily.com)
There has been gradual melting and recession of Arctic sea ice with extreme loss in 2007 rendering the Northwest Passage «fully navigable». (en.wikipedia.org)
So many of the characters in «Hostiles» are propelled forward by extreme loss or extreme violence. (backstage.com)