About 1 in 20 people with melanoma have a strong family history of the disease. (sciencedaily.com)
If the disease is uncommon, as with the progressive rod - cone degeneration (PRCD) form of Progressive Retinal Atrophy in Australian Shepherds, or if use of a test and careful breeding decisions have markedly reduced the frequency of a formerly common mutation (think what could be done with CEA in Collies,) testing could then be confined to only those dogs with known family history of the disease or with relatives that have been DNA tested as carriers. (ashgi.org)
Adverse psychosocial experiences in childhood are likely to be accompanied by other developmental risk factors for poor adult health, including family history of disease, 38 low birth weight, 39 and childhood overweight.40 It is thus important to test whether adverse psychosocial experiences in childhood exert an influence on adult outcomes that is independent of these established risk factors. (jamanetwork.com)