Changes to the hierarchy only happen if you die, interfere in specific events, or manually skip time at fast travel stations. (impulsegamer.com)
Fixed fast travel stations from downloadable content sometimes disappearing when loading a saved game. (gearboxsoftware.zendesk.com)
The bad part of having to buy your weapons, clothing, and etc..., you have to go back to your base which is in another city from all the missions so it gets a little tedious having to go back and forth to make changes to your equipment; fortunately, there are fast travel stations throughout the game. (gamegravy.com)