This activity results in amplification of canonical WNT signaling in presumptive joint cells and perichondrium cells and thus in securing the non-chondrogenic fate of these cells. (lerner.ccf.org)
OMP - 54F28 (FZD8 - Fc) is an antagonist of the Wnt pathway, a key CSC signaling pathway that regulates the fate of these cells. (sciencedaily.com)
Each ended up taking on the characteristics of its new neighbors, implying that the environment that they grew up in strongly influenced the fate of these cells. (sciencedaily.com)