Two protein molecules that fit together as lock and key seem to promote the abnormal formation of blood vessels in joints affected by rheumatoid arthritis, according to researchers at the University of Illinois at Chicago College of Medicine, who found that the substances are present at higher levels in the joints of patients affected by the disease. (sciencedaily.com)
In particular they highlight molecular crosstalk between a signaling protein that cells produce to stimulate formation of blood vessels (VEGF) and a protein and receptor that communicates with VEGF to help trigger formation of a blood supply to the developing liver (KDR). (sciencedaily.com)
With chronic or long - standing distichiasis, the dog will often develop corneal scarring (white areas on the cornea), hyperpigmentation (dark areas on the cornea), or corneal neovascularization (abnormal formation of blood vessels across the surface of the cornea). (glenerinanimalhospital.com)