Phrases with «frameshift mutation»

A "frameshift mutation" is a type of genetic change that occurs when the letters of DNA are added or removed, changing the reading frame. This causes a disruption in the instructions for building proteins, leading to faulty or non-functional proteins being made. Full definition

frameshift mutation

Sentences with «frameshift mutation»

DMD is caused primarily by frameshift mutations in dystrophin, a protein essential for proper muscle function. (blog.addgene.org)
Surprisingly, frameshift mutations occurred at a ratio of 0.90 in - frame per out - of - frame mutation as opposed to the expected frequency of 0.50 (1 in - frame per 2 out - of - frame mutations; Table S1). (journals.plos.org)
However, while CRISPR is remarkably effective for introducing non-sequence specific frameshift mutations through aberrant double strand break repair, it has proven more challenging to develop high efficiency CRISPR - based approaches for the generation of knockins via homologous recombination with a homologous repair template. (blog.addgene.org)
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Phrases with «frameshift mutation»

Sentences with «frameshift mutation»

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