Individual DNA bases can be chemically modified, with significant functional consequences. (sciencedaily.com)
The lab has been developing computational methods and tools to allow researchers and clinicians to identify functional consequences of genetic variations within cis - regulatory elements such as transcription factor binding sites. (bcchr.ca)
Future work to correlate these mutations with functional consequences in brain development should not only increase the understanding of how autism is caused, but also enable a more accurate diagnosis of autism and other ASDs. (sciencedaily.com)