Construction of somatic cellular knockout models for the determination of protein functional impacts on various cellular processes: (mdanderson.ilabsolutions.com)
Jacob A. Tennessen et al., «Evolution and Functional Impact of Rare Coding Variations from Deep Sequencing of Human Exomes,» Science, Vol. (creationscience.com)
Since the mutations in offspring of younger fathers tend to occur in these regions, they're less likely to have a functional impact. (massgenomics.org)