Cancer progression involves fundamental alterations of cell - cell and cell - matrix interactions and the cues derived from them that contribute to the invasive and metastatic phenotype. (vicc.org)
But once their peers saw that it involved fundamental alterations to Bitcoin's source code, they resisted. (profitconfidential.com)
There won't be a moment of revolution, but only incremental changes which, perhaps decades from now, perhaps only on even longer - term scales, will only in hindsight be revealed as fundamental alterations — and perhaps not even that. (law21.ca)