The succession of scientific discoveries and revolutions in physics over the last 500 years have led to fundamental paradigm shifts (Kuhn, The Structure of Scientific Revolutions, 1962) in the way that science conceives of the reality of this universe both on the cosmological scale and in the subatomic realm, and perhaps even beyond this universe. (faith.org.uk)
Indeed, this new method of genetic analysis represents a fundamental paradigm shift in biology. (sciencemag.org)