They used state of the art genetic mouse models to study different stem cells populations. (sciencedaily.com)
Morgan Fullerton, lead author of the study, added: «Unlike the majority of studies using genetic mouse models, we haven't deleted an entire protein; we have only made a very minor genetic mutation, equivalent to what might be seen in humans, thus highlighting the very precise way metformin lowers blood sugar in Type 2 Diabetes» (sciencedaily.com)
When the system was applied in genetic mouse models, the team could see specifically how sensory, motor, and reward structures in the brain connected to MSNs in the basal ganglia. (gladstone.org)