Loss of heterochromatin regulation has potential consequences for the long - term genetic stability of stem cells, and the ability of stem cells to mature into specialised cell types. (sciencedaily.com)
However, the long - term genetic stability of this cell type remains to be determined, so as to avoid tumor formation following therapeutic cell transplantations. (discovery.lifemapsc.com)
The results of this study, published now in the open access journal PLOS Biology, raise the possibility that chromosome rearrangements involving these regions, often seen in many cancers, can induce additional errors in cell division and thereby compromise genetic stability. (sciencedaily.com)