The phrase "genomic deletions" refers to a type of genetic change where a section of DNA is missing or deleted. It means that part of the genetic instructions that are normally present in an organism's DNA is no longer there. Full definition
Very recently the causal mutation has been identified by two research groups almost simultaneously, as a large genomic deletion of ADAM9 (A Disintegrin And Metalloprotease domain, family member 9) that removes exons 15 and 16 of the ADAM9 transcript [53, 54] and generates a premature stop codon that is predicted to result in a truncated protein that lacks critical domains. (cgejournal.biomedcentral.com)
«Genetic engineering of human stem cells has not been used for disease - associated genomic deletions,» said Dr. Papapetrou. (sciencedaily.com)
Therefore, NHEJ repair can only be used to create short genomic deletions, but does not support precise gene modification or the insertion and replacement of gene segments. (sciencedaily.com)