For a positive control, nuclear extracts were prepared from a rat C6 glioblastoma cell line incubated in the presence of CoCl2 for 2 h. CoCl2 is known to increase HIF - 1α protein levels [55]. (molvis.org)
Prabhu and colleagues conducted a gene expression analysis of colorectal, prostate cancer and glioblastoma cell lines and patient - derived tissues that were both treated with ONC201. (sciencedaily.com)
His team identified a factor that may be important for clinical trial design: progesterone was not toxic to all glioblastoma cell lines, and its toxicity may depend on whether the tumor suppressor gene p53 is mutated. (emoryhealthsciblog.com)