Another example of such differences (when looking at individual cells versus the whole body) relates to the differential effects of injury and sepsis on glucose production in the liver when isolated liver cells are used versus measuring gluconeogenesis in the whole body where other hormone, cytokine and other effects come into play. (sciencemediacentre.org)
Metformin is used to lower blood glucose levels by reducing glucose production in the liver. (sciencedaily.com)
The disease is often linked to obesity and insulin resistance and a loss of control of glucose production in the liver and insulin production in the pancreas, resulting in too much glucose in the blood. (sciencedaily.com)