An immune system proteinase called granzyme A appears to promote arthritic inflammation in mice infected with chikungunya virus, scientists report in a new PLOS Pathogens study. (sciencedaily.com)
Lieberman notes that her laboratory reported a similar reaction to perforin, granulysin and granzyme in intracellular bacteria in a 2014 Cell paper. (sciencedaily.com)
They also found elevated granzyme A levels in blood samples taken from non-human primates infected with chikungunya, as well as from human chikungunya patients. (sciencedaily.com)