Through interaction with the cdk / cyclin complexes, p21waf1 / cip1 modulates their kinase activity, resulting in cell growth arrest (10). (cancerres.aacrjournals.org)
Oncostatin M Induces Growth Arrest by Inhibition of Skp2, Cks1, and Cyclin A Expression and Induced p21 Expression (cancerres.aacrjournals.org)
In addition, ActD has been shown to mimic nutlin - 3 in the activation of p53 - dependent transcription, induction of a reversible protective growth arrest in normal cells, and enhancement of the activity of the chemotherapeutic drugs, melphalan and etoposide, resulting in apoptosis of p53 positive human tumor cells [14]. (oncotarget.com)