Large breeds typically have different nutrient requirements than smaller breeds in order to promote and maintain healthy bone structure. (thehappypuppysite.com)
Studies of paleolithic humans by anthropologist have indeed revealed that our ancestors had healthier bone structures with little to no evidence of bone loss or decay and very little joint -LSB-...] (deliciousbydre.com)
It's also been proven to have anti-depressing effects and can help maintain healthy bone structure as well as a stronger immune system. (fitnessandpower.com)