DDX3 harbors nucleotide triphosphatase - deoxynucleotide triphosphatase activity (1), ATPase - dependent RNA helicase activity, and a nuclear - cytoplasmic shuttling localization function (5). (cancerres.aacrjournals.org)
Because a similar expression level of these three DDX3 expression constructs was detected (data not shown), their differential induction of p21waf1 / cip1 promoter activity suggests that the ATPase activity, but not the RNA helicase activity, contributes to the transcriptional activation of DDX3 on the p21waf1 / cip1 promoter. (cancerres.aacrjournals.org)
He plans to use the grant to develop novel functions in helicase enzymes to enable low - cost diagnostics in point - of - care and low - resource settings. (hopkinsmedicine.org)