The team did this using stem cells from human cord blood, inducing them to become pluripotent stem cells capable of becoming any type of cell. (newscientist.com)
Valproate treatment of human cord blood CD4 - positive effector T cells confers on them the molecular profile (microRNA signature and FOXP3 expression) of natural regulatory CD4 - positive cells through inhibition of histone deacetylase. (jimmunol.org)
In addition, VPA was shown to confer the molecular profile, including microRNA signature and FOXP3 expression, of natural Tregs to human cord blood CD4 + effector T cells (40). (jimmunol.org)