they may need leptin infusions to offset the loss of hypocretin neurons in the hypothalamus from years of damage. (jackkruse.com)
Using gene mapping techniques, the researchers zeroed in on a mutation in the gene for hypocretin receptor 2. (sciencemag.org)
Researchers have engineered the genomes of mice so they have a light - sensitive inhibitory molecule that can shut down the wakefulness - promoting properties of neurons called hypocretin cells. (aaas.org)