Veland N, Hardikar S, Zhong Y, Gayatri S, Dan J, Strahl BD, Rothbart SB, Bedford MT, Chen T. (2017) The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer. (mdanderson.org)
This unbiased approach revealed global hypomethylation in the cancer cell line (HCC1954) relative to epithelial cells (HMEC), and some specific patterns: (massgenomics.org)
The next part is to predict the risk of individual dogs, and to treat hyper or hypomethylation with drugs, expand the study to other breeds and preventative medication to dogs at risk. (colliehealth.org)