«It is now possible to identify children at increased risk for type 1 diabetes at birth, and there is an identifiable sequence of events that culminates in impaired insulin secretion and overt type 1 diabetes,» writes Jay S. Skyler, M.D., of the University of Miami Miller School of Medicine, in an accompanying editorial. (sciencedaily.com)
The relevance to account for the major pathophysiological mechanisms of diabetes can be observed that in diabetes diagnosed by elevated fasting or 2 hr glucose levels during a standard oral glucose tolerance test (OGTT) the prevalence and the sequence of appearance of impaired insulin production and impaired insulin secretion differ. (sciencedaily.com)
Type 2 diabetes results from impaired insulin secretion combined with impaired insulin action, which is also referred to as decreased insulin sensitivity or insulin resistance (21). (academic.oup.com)