The result was a relative state of hypoxia or inadequate oxygen supply, one that subsequently induced production of a protective transcription factor in fat cells called HIF - 1alpha. (sciencedaily.com)
Possible Health Indication: Poor liver function, joint complications, poor digestion and / or inadequate oxygen in the body (drjockers.com)
Any type of respiratory distress should be seen by your Veterinarian especially if you are seeing dark pink gums with some blue spots which disappear when respiration increases is indicative of inadequate oxygen being supplied to the blood, this may be due to lung problems or blood problems (carbon monoxide poisoning for example). (wagwalking.com)